研究进展（2025）

1. Deacetylation of nuclear AIF provides a braking mechanism for caspase-independent chromatinolysis and necrotic brain injury. Hu C, Geng J, Shan P, Zhang T, Zhang Z, Zhang X, Lin M, Zhang X, Chang D, He B, Jia D, Zhang M, Wang C, Zhang S. Commun Biol. 2025 May 27;8(1):813. doi: 10.1038/s42003-025-08255-w.

2. A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders. Li L, Li T, Liang X, Zhu L, Fang Y, Dong L, Zheng Y, Xu X, Li M, Cai T, Zhao F, Xin M, Shao M, Guan Y, Liu M, Li F, Zhang C, Wang Q, Sun W, Zheng Y. Cell Discovery 2025 Mar 17;11(1):25. doi: 10.1038/s41421-025-00789-x.

3. Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy. Sun L, Fan G, Zhang Z, Chang D, Zhang X, Zhang T, Geng J, Zhang X, Lin M, Hu C, Zhou J, Wang M, Cao L, Zhang M, He B, Zhang S, Wang C. Cell Reports 2025 Feb 25;44(2):115269. doi: 10.1016/j.celrep.2025.115269.